Relaxin and gastrointestinal motility

Maria C. Baccari, Roberta Squecco, Rachele Garella


Relaxin is involved in a variety of functions. Among them, relaxin influences gastrointestinal motility in mice mainly regulating the biosynthesis of nitric oxide, considered as the main substance causing smooth muscle relaxations. Relaxin is able to regulate the different nitric oxide synthase expression depending on the gut region considered. Relaxin also counteracts the hypermotility state, related to a defective nitric oxide production, observed in the gut of dystrophic (mdx) mice. From the above considerations, it appears that relaxin, in addition to its physiological roles, may be regarded as a therapeutic tool in gastrointestinal diseases characterized pathogenically by an altered nitric oxide production.


relaxin; nitric oxide; gastrointestinal motility

Full Text:



Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License (CC-BY- 4.0)

Firenze University Press
Via Cittadella, 7 - 50144 Firenze
Tel. (0039) 055 2757700 Fax (0039) 055 2757712